They’re out for a good cause.

Jessica Biel made a rare appearance with her and Justin Timberlake’s sons, Silas, 9, and Phineas, 4, and her niece Zaya, 5, at a fashion show for the Global Down Syndrome Foundation in Denver.

On Saturday, the “7th Heaven” alum, 42, looked thrilled as she walked the runway with her kids and niece.

Jessica Biel, pictured here with her son Silas and niece Zaya, made a rare appearance with her kids at a Global Down Syndrome Foundation charity event. Jensen Sutta for Global Down Syndrome Foundation

Zaya, who has Down syndrome, led the way in front of her aunt and two cousins.

The young girl was honored as Global’s ambassador at the Be Beautiful Be Yourself Fashion Show.

The mom of two stunned in a black jumpsuit that was accentuated with black feathers across the chest and shoulders. Biel wore her blond locks in a blunt bob cut and wore minimal makeup.

Zaya was honored as Global’s ambassador at the Be Beautiful Be Yourself Fashion Show. Jensen Sutta for Global Down Syndrome Foundation

Biel rarely makes public appearances with her sons.

Silas rocked a pair of khaki slacks, a white button-up shirt and a dark blue blazer.

After the event, Jessica took to social media to share more pictures from the night, including a photo with Zaya’s parents: her brother, Justin Biel, and his wife, Rose Biel.

“Last night was truly special at the #BeBeautifulBeYourself fashion show. Walking the runway with my amazing niece @lovelyzayab was an unforgettable honor,” she captioned the post.

The mom of two stunned in a black jumpsuit that was accentuated with black feathers across the chest and shoulders. Getty Images for Global Down Syndrome Foundation

“Huge thanks to the @globaldownsyndrome foundation for creating such a profound, empowering event and for all the incredible work you do. My heart is so full. ”

Timberlake, 43, was not present for the event, as he is currently on a world tour.

Biel and the *NSYNC frontman, who have been married since 2012, only show the back of their kids’ heads on Instagram.

Timberlake was not present for the event, as he is currently on a world tour. Getty Images for American Express

The “Mirrors” singer and the “Candy” star tied the knot in 2012. jessicabiel/Instagram

The “Candy” actress previously said they wanted to “create some normalcy” for their children.

“We understand that our job has this major public-facing element, but these kids didn’t choose this. I don’t want to expose them in a way until they have an ability to make the decision for themselves,” she told Kelly Ripa on the “Let’s Talk Off Camera” podcast in May.

“I just don’t want [their exposure] to be on my account,” she continued. “No disrespect to anyone who feels comfortable doing that, that’s just our family choice. Maybe it’s a mistake. I don’t know.”